Pax6^em1Jkm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pax6^em1Jkm
• Name: paired box 6; endonuclease-mediated mutation 1, Jin Woo Kim
• MGI ID: MGI:6203122
• Synonyms: Pax6^deltaPBS
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^em1Jkm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 6bp deletion (5'-TGCATG-3') in the auto-regulatory Pax6 binding sequence upstream of exon 5. (J:240931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 93 strains or lines available

References

• Original: J:240931 Kim Y, et al., The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity. Elife. 2017 Jan 31;6:e21303
• All: 1 reference(s)