Gps2^tm1.1Vper
Targeted Allele Detail

Summary

• Symbol: Gps2^tm1.1Vper
• Name: G protein pathway suppressor 2; targeted mutation 1.1, Valentina Perissi
• MGI ID: MGI:6203087
• Synonyms: Gps2^fl
• Gene: Gps2 Location: Chr11:69804714-69807417 bp, + strand Genetic Position: Chr11, 42.92 cM
• Alliance: Gps2^tm1.1Vper page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240887
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 6. Flp mediated recombination removed the neo cassette. (J:240887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gps2 Mutation: 21 strains or lines available

References

• Original: J:240887 Lentucci C, et al., Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17;292(7):2754-2772
• All: 4 reference(s)