Prox1^tm1.1Ykaw
Targeted Allele Detail

Summary

• Symbol: Prox1^tm1.1Ykaw
• Name: prospero homeobox 1; targeted mutation 1.1, Yoshiya Kawaguchi
• MGI ID: MGI:6203069
• Synonyms: Prox1^loxP
• Gene: Prox1 Location: Chr1:189850232-189902911 bp, - strand Genetic Position: Chr1, 95.85 cM
• Alliance: Prox1^tm1.1Ykaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240871
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream on exon 2 and a loxP site and an FRT flanked pgk-neo cassette were inserted in intron 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:240871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prox1 Mutation: 43 strains or lines available

References

• Original: J:240871 Goto T, et al., Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice. FEBS Lett. 2017 Feb;591(4):624-635
• All: 2 reference(s)