Sorl1^em1Adiuj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sorl1^em1Adiuj
• Name: sortilin-related receptor, LDLR class A repeats-containing; endonuclease-mediated mutation 1, MODEL-AD Center
• MGI ID: MGI:6202984
• Synonyms: Sorl1^A528T
• Gene: Sorl1 Location: Chr9:41876016-42035593 bp, - strand Genetic Position: Chr9, 23.55 cM, cytoband B
• Alliance: Sorl1^em1Adiuj page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Plasmids encoding a single guide RNA designed to introduce the A528T point mutation (GCC to ACC; modeling human variant rs2298813) and silent R529R mutation into the gene and the cas9 nuclease were introduced into the cytoplasm of fertilized eggs with well recognized pronuclei. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sorl1 Mutation: 131 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)