Lhfpl4^em1Jxia
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lhfpl4^em1Jxia
• Name: lipoma HMGIC fusion partner-like protein 4; endonuclease-mediated mutation 1, Jun Xia
• MGI ID: MGI:6202596
• Gene: Lhfpl4 Location: Chr6:113145051-113172345 bp, - strand Genetic Position: Chr6, 52.74 cM
• Alliance: Lhfpl4^em1Jxia page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 14bp deletion in exon 2. Western blot analysis detected weak expression of a slightly smaller molecular weight protein. (J:265620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhfpl4 Mutation: 12 strains or lines available

References

• Original: J:265620 Wu M, et al., Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 2018 May 8;23(6):1691-1705
• All: 1 reference(s)