Hipk2^tm1.1Tgh
Targeted Allele Detail

Summary

• Symbol: Hipk2^tm1.1Tgh
• Name: homeodomain interacting protein kinase 2; targeted mutation 1.1, Thomas G Hofmann
• MGI ID: MGI:6202124
• Synonyms: Hipk2^flox, Hipk2tm1Tgh
• Gene: Hipk2 Location: Chr6:38671325-38853099 bp, - strand Genetic Position: Chr6, 17.85 cM, cytoband B
• Alliance: Hipk2^tm1.1Tgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265693
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and F3 flanked puro cassette was inserted upstream of exon 3 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo and puro cassettes leaving exons 3 and 4 floxed. (J:265693)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hipk2 Mutation: 52 strains or lines available

References

• Original: J:265693 Rattay K, et al., Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. J Immunol. 2015 Feb 1;194(3):921-8
• All: 2 reference(s)