Il25^tm1.1Lky
Targeted Allele Detail

Summary

• Symbol: Il25^tm1.1Lky
• Name: interleukin 25; targeted mutation 1.1, Richard M Locksley
• MGI ID: MGI:6202117
• Synonyms: Il25^F25, Il25^Flare25
• Gene: Il25 Location: Chr14:55170152-55173294 bp, + strand Genetic Position: Chr14, 28.0 cM
• Alliance: Il25^tm1.1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265419
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked with loxP sites and an IRES-tandem-dimer red fluorescent protein-polyA reporter construct and an FRT flanked neo cassette were inserted in the 3'UTR via homologous recombination. Flp mediated recombination removed the neo cassette. (J:265419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il25 Mutation: 17 strains or lines available

References

• Original: J:265419 von Moltke J, et al., Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14;529(7585):221-5
• All: 9 reference(s)