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Ntsr2tm1.1(cre)Giml
Targeted Allele Detail
Nomenclature
Symbol: Ntsr2tm1.1(cre)Giml
Name: neurotensin receptor 2; targeted mutation 1.1, Gina M Leinninger
MGI ID: MGI:6202113
Synonyms: NtsR2deltaNEO-Cre, NtsR2Dev
Gene: Ntsr2  Location: Chr12:16653451-16660236 bp, + strand  Genetic Position: Chr12, 7.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:263745
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR2 gene, with an FRT-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Mice were bred to a FlpO deleter line to remove neo cessette to make constitutive cre expression throughout life. (J:263745)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ntsr2     Summary of all recombinase alleles driven by Ntsr2. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntsr2 Mutation:  14 strains or lines available
References
Original:  J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1)
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory