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Ntsr2tm1(cre)Giml
Targeted Allele Detail
Nomenclature
Symbol: Ntsr2tm1(cre)Giml
Name: neurotensin receptor 2; targeted mutation 1, Gina M Leinninger
MGI ID: MGI:6202109
Synonyms: NtsR2Adult, NtsR2NEO-Cre
Gene: Ntsr2  Location: Chr12:16653451-16660236 bp, + strand  Genetic Position: Chr12, 7.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:263745
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    FlpO
Mutation:    Insertion
 
Mutation detailsThe targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR2 gene, with an frt-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Presence of frt-flanked NEO cassette prevents cre expression until exposure to FlpO. (J:263745)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ntsr2     Summary of all recombinase alleles driven by Ntsr2. Comparative matrix view of recombinase activities
User Notes:
 Additional information submitted by the research community
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntsr2 Mutation:  14 strains or lines available
References
Original:  J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory