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Targeted Allele Detail
Symbol: Ntsr1tm1(cre)Giml
Name: neurotensin receptor 1; targeted mutation 1, Gina M Leinninger
MGI ID: MGI:6202108
Synonyms: NtsR1Adult, NtsR1NEO-Cre
Gene: Ntsr1  Location: Chr2:180499976-180544979 bp, + strand  Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
Germline Transmission:  Earliest citation of germline transmission: J:263745
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    FlpO
Mutation:    Insertion
Mutation detailsThe targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR1 gene, with an frt-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Presence of frt-flanked NEO cassette prevents cre expression until exposure to FlpO. (J:263745)
 Tissue activity of this recombinase allele
Driver: Ntsr1     Summary of all recombinase alleles driven by Ntsr1. Comparative matrix view of recombinase activities
User Notes:
 Additional information submitted by the research community

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntsr1 Mutation:  19 strains or lines available
Original:  J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory