Rag1^em4Ldn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag1^em4Ldn
• Name: recombination activating 1; endonuclease-mediated mutation 4, Luigi D Notarangelo
• MGI ID: MGI:6202081
• Synonyms: R972W
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^em4Ldn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination induced a C to T mutation at position 2914 (c.2914C>T) resulting in an arginine 972 tryptophan missense mutation. (J:264758)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 120 strains or lines available

References

• Original: J:264758 Ott de Bruin LM, et al., Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development. Blood. 2018 Jul 19;132(3):281-292
• All: 1 reference(s)