Pik3cd^tm1.1Klog
Targeted Allele Detail

Summary

• Symbol: Pik3cd^tm1.1Klog
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1.1, Klaus Okkenhaug
• MGI ID: MGI:6202025
• Synonyms: p110d-E1020K-fl, p110d-E1020K-gl
• Gene: Pik3cd Location: Chr4:149733625-149787023 bp, - strand Genetic Position: Chr4, 80.15 cM
• Alliance: Pik3cd^tm1.1Klog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265645
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed duplication of the last exon carrying the E1020K mutation was inserted 3' to the endogenous sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon. (J:265645)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cd Mutation: 43 strains or lines available

References

• Original: J:265645 Stark AK, et al., PI3Kdelta hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nat Commun. 2018 Aug 9;9(1):3174
• All: 2 reference(s)