Slc3a1^tm1Jat
Targeted Allele Detail

Summary

• Symbol: Slc3a1^tm1Jat
• Name: solute carrier family 3, member 1; targeted mutation 1, Jay A Tischfield
• MGI ID: MGI:6202022
• Gene: Slc3a1 Location: Chr17:85335804-85371664 bp, + strand Genetic Position: Chr17, 55.17 cM
• Alliance: Slc3a1^tm1Jat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254803
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector replaced 5.7 kb of the sequence that includes exon 1 with a 1.7-kb neomycin cassette under the control of a PGK1 promoter. (J:254803)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc3a1 Mutation: 37 strains or lines available

References

• Original: J:254803 Zee T, et al., alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med. 2017 Mar;23(3):288-290
• All: 4 reference(s)