Tg(Hpgds-tdTomato,-DTA)1Jay
Transgene Detail

Summary

• Symbol: Tg(Hpgds-tdTomato,-DTA)1Jay
• Name: transgene insertion 1, Philippe Jay
• MGI ID: MGI:6201708
• Synonyms: Hpgds^tdTomato
• Transgene: Tg(Hpgds-tdTomato,-DTA)1Jay Location: unknown
• Alliance: Tg(Hpgds-tdTomato,-DTA)1Jay page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-tdTomato-Stop-polyA-loxP-diptheria toxin A (DTA) cassette was introduced to mouse BAC (MSMg01-143H02) containing the Hpgds gene exon2 downsterem and in frame with the start codon. In presence of cre recombinase, the tdTomato reporter cassette is excised, allowing expression of DTA and ablation of the expressing cells. Thtee founders animals were initialy created, but only one line was maintained. Only one line of this strain (line 1) is available. (J:265285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:265285 Bornstein C, et al., Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells. Nature. 2018 Jul;559(7715):622-626
• All: 1 reference(s)