Tg(Myh6-Tnni3*S23A*S24D*S43D*S45D)354Ammu
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*S23A*S24D*S43D*S45D)354Ammu
• Name: transgene insertion 354, Anne Murphy
• MGI ID: MGI:6201702
• Synonyms: TnI PKA/PKC
• Transgene: Tg(Myh6-Tnni3*S23A*S24D*S43D*S45D)354Ammu Location: unknown
• Alliance: Tg(Myh6-Tnni3*S23A*S24D*S43D*S45D)354Ammu page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Myh6-Tnni3*S23A*S24D*S43D*S45D)354Ammu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tnni3 (29248)

  Tnni3

  (MGI:98783)

  rat cDNA carrying a S22A S23D S42D S44D substitution

• Mutation details: The transgene was designed with the mouse alpha-myosin heavy chain (Myh6) promoter directing expression of a modified rat troponin I, cardiac 3 (Tnni3) cDNA. The Tnni3 sequence encodes a protein containing a serine to alanine substitution at residue 23 (S23A), a serine to aspartic acid substitution at residue 24 (S24D) and serine to aspartic acid substitutions at residues 43 and 45 (S43D, S45D) (mRNA RefSeq: NM_017144.2; protein RefSeq: NP_058840.1). (These amino acid positions differ by one from those reported, which were based on the mature peptide sequence lacking the initiating methionine.) Founder line 354 was selected as the representative line. (J:119966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:119966 Bilchick KC, et al., Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H318-25
• All: 1 reference(s)