Tg(Myh6-Tnni3*S23D*S24D)69Ammu
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*S23D*S24D)69Ammu
• Name: transgene insertion 1, Anne Murphy
• MGI ID: MGI:6201700
• Synonyms: TnIDD22,23
• Transgene: Tg(Myh6-Tnni3*S23D*S24D)69Ammu Location: unknown
• Alliance: Tg(Myh6-Tnni3*S23D*S24D)69Ammu page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Myh6-Tnni3*S23D*S24D)69Ammu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tnni3 (29248)

  Tnni3

  (MGI:98783)

  rat cDNA carrying a S22D S23D substitution

• Mutation details: The transgene was designed with the mouse alpha-myosin heavy chain (Myh6) promoter directing expression of a modified rat troponin I, cardiac 3 cDNA sequence. The Tnni3 sequence contains serine to aspartic acid substitutions at residues 23 and 24 (S23D, S24D) (mRNA RefSeq: NM_017144.2; protein RefSeq: NP_058840.1), mimicking the effects of constitutive phosphorylation by protein kinase A. (These amino acid positions differ by one from those reported, which were based on the mature peptide sequence lacking the initiating methionine.) (J:96616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96616 Takimoto E, et al., Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. Circ Res. 2004 Mar 5;94(4):496-504
• All: 1 reference(s)