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Targeted Allele Detail
Symbol: Slc9a9tm2c(KOMP)Wtsi
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9; targeted mutation 2c, Wellcome Trust Sanger Institute
MGI ID: MGI:6201439
Gene: Slc9a9  Location: Chr9:94669909-95230445 bp, + strand  Genetic Position: Chr9, 49.22 cM
Germline Transmission:  Earliest citation of germline transmission: J:258593
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 94809441 of Chromosome 9 upstream of the exon 5 (Build GRCm38). The cassette is composed of an FRT site followed by a lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, an SV40 polyA cassette, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 5 at position 94810324. Exon 5 is thus flanked by loxP sites. Flp mediated recombination created a "conditional ready" (floxed) allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:258593)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc9a9 Mutation:  21 strains or lines available
Original:  J:258593 Ullman JC, et al., A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. Nat Commun. 2018 Jan 23;9(1):330
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory