Crhr1^tm3Jde
Targeted Allele Detail

Summary

• Symbol: Crhr1^tm3Jde
• Name: corticotropin releasing hormone receptor 1; targeted mutation 3, Jan Deussing
• MGI ID: MGI:6201417
• Synonyms: Crhr1^tZ-deltaloxP
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^tm3Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264526
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (RMCE-ready)
• Mutation: Insertion
• Mutation details: A construct with a docking site for recombinase-mediated cassette exchange (RMCE) contained (5' to 3') an attP site, loxP site, FRT site, splace acceptor, T2A cleavage site, tau/lacZ/flag reporter cassette, FRT site, neo cassette, attP site, PGK promoter and FRT site, was inserted into intron 2. (J:264526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 26 strains or lines available

References

• Original: J:264526 Dedic N, et al., Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 Jun;21(6):803-807
• All: 1 reference(s)