Sox7^em2Yokan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sox7^em2Yokan
• Name: SRY (sex determining region Y)-box 7; endonuclease-mediated mutation 2, Yoshiakira Kanai
• MGI ID: MGI:6201361
• Synonyms: Sox7-null
• Gene: Sox7 Location: Chr14:64181155-64188181 bp, + strand Genetic Position: Chr14, 33.34 cM, cytoband C3
• Alliance: Sox7^em2Yokan page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 sequence coding for the HMG box was targeted with oligonucleotides and sgRNAs using CRISPR/Cas9 technology. Three mouse lines with null alleles were established. This allele has a 28 bp deletion in the HMG box sequence that leads to a frameshift and a premature stop codon after 40 out-of-frame codons. (J:265463)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox7 Mutation: 21 strains or lines available

References

• Original: J:265463 Igarashi H, et al., Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk. Biol Reprod. 2018 Sep 1;99(3):578-589
• All: 1 reference(s)