Avil^{tm2(CHRM3*-mCherry)Phep}
Targeted Allele Detail

Summary

• Symbol: Avil^{tm2(CHRM3*-mCherry)Phep}
• Name: advillin; targeted mutation 2, Paul A Heppenstall
• MGI ID: MGI:6201345
• Synonyms: Avil^{hM3Dq-mCherry}
• Gene: Avil Location: Chr10:126836578-126856863 bp, + strand Genetic Position: Chr10, 74.48 cM, cytoband D3
• Alliance: Avil^{tm2(CHRM3*-mCherry)Phep} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265202
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Lox-STOP-Lox-hM3Dq-mCherry cassette was inserted into the Advilin locus, to replace exon 2 and 66 bp upstream of Avil gene. It is a cre dependent reporter allele in which sensory neuron-specific Avil drives expression of mCherry in response to cre recomibination. (J:265202)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avil Mutation: 46 strains or lines available

References

• Original: J:265202 Dhandapani R, et al., Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. 2018 Apr 24;9(1):1640
• All: 2 reference(s)