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Targeted Allele Detail
Symbol: Cdk10tm1.2Kald
Name: cyclin-dependent kinase 10; targeted mutation 1.2, Philipp Kaldis
MGI ID: MGI:6201331
Synonyms: Cdk10null
Gene: Cdk10  Location: Chr8:123224842-123232250 bp, + strand  Genetic Position: Chr8, 72.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:262333
Parent Cell Line:  S1B6 (ES Cell)
Strain of Origin:  129S1/SvImJ or C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 8. (J:262333)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk10 Mutation:  8 strains or lines available
Original:  J:262333 Windpassinger C, et al., CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. Am J Hum Genet. 2017 Sep 7;101(3):391-403
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory