Ifnlr1^tm1.2Svko
Targeted Allele Detail

Summary

• Symbol: Ifnlr1^tm1.2Svko
• Name: interferon lambda receptor 1; targeted mutation 1.2, Sergei V Kotenko
• MGI ID: MGI:6200891
• Synonyms: Ifnar1^-
• Gene: Ifnlr1 Location: Chr4:135413598-135435492 bp, + strand Genetic Position: Chr4, 67.94 cM
• Alliance: Ifnlr1^tm1.2Svko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253552
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. Floxed exon 3 was deleted through subsequent cre-mediated recombination. (J:253552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnlr1 Mutation: 38 strains or lines available

References

• Original: J:253552 Lin JD, et al., Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections. PLoS Pathog. 2016 Apr;12(4):e1005600
• All: 10 reference(s)