Lrfn2^tm1.2Csbd
Targeted Allele Detail

Summary

• Symbol: Lrfn2^tm1.2Csbd
• Name: leucine rich repeat and fibronectin type III domain containing 2; targeted mutation 1.2, Eunjoon Kim
• MGI ID: MGI:6200740
• Gene: Lrfn2 Location: Chr17:49239407-49404616 bp, + strand Genetic Position: Chr17, 24.66 cM, cytoband C
• Alliance: Lrfn2^tm1.2Csbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263547
• Parent Cell Line: C57BL/6J-693 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct is composed of an FRT site, EGFP, a loxP site, a neomycin cassette, and an FRT site upstream of exon 2. A second loxP is inserted site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked EGFP and neo cassette leaving exon 2 floxed. Cre-mediated recombination removed exon 2. Immunoblot analysis confirms the absence of protein in the hippocampus. (J:263547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrfn2 Mutation: 45 strains or lines available

References

• Original: J:263547 Li Y, et al., Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response. J Neurosci. 2018 Jun 27;38(26):5872-5887
• All: 1 reference(s)