Gpr119^tm1.1Ddr
Targeted Allele Detail

Summary

• Symbol: Gpr119^tm1.1Ddr
• Name: G-protein coupled receptor 119; targeted mutation 1.1, Daniel J Drucker
• MGI ID: MGI:6199061
• Gene: Gpr119 Location: ChrX:47756856-47763355 bp, - strand Genetic Position: ChrX, 25.69 cM
• Alliance: Gpr119^tm1.1Ddr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246169
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exon 1 and into intron 2. An FRT site flanked neomycin resistance gene cassette that was also inserted was removed through subsequent flp-mediated recombination. This leaves a conditional-ready allele with exon 1 floxed. (J:246169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr119 Mutation: 8 strains or lines available

References

• Original: J:246169 Panaro BL, et al., beta-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation. Diabetes. 2017 Jun;66(6):1626-1635
• All: 1 reference(s)