Ptpn6^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptpn6^m4Btlr
• Name: protein tyrosine phosphatase, non-receptor type 6; mutation 4, Bruce Beutler
• MGI ID: MGI:6199040
• Synonyms: farfalla_norttuna
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 124,732,435 (v38) on chromosome 6, or base pair 6,275 in the GenBank genomic region NC_000072. The mutation corresponds to residue 392 in the mRNA sequence NM_013545 within exon 3 of 16 total exons. The mutation results in a tyrosine to cysteine substitution at position 64 (Y64C) in variant 1 of the SHP1 protein. (J:264807)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 47 strains or lines available

References

• Original: J:264807 Choi JH, et al., Choi JH; Zhong X; Nair-GillMutagenetix entry for farfalla_norttuna. MGI Direct Data Submission. 2018
• All: 1 reference(s)