Hmgcr^tm1.1Awai
Targeted Allele Detail

Summary

• Symbol: Hmgcr^tm1.1Awai
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; targeted mutation 1.1, Ari Waisman
• MGI ID: MGI:6198342
• Synonyms: Hmgcr^fl
• Gene: Hmgcr Location: Chr13:96785475-96807444 bp, - strand Genetic Position: Chr13, 50.65 cM
• Alliance: Hmgcr^tm1.1Awai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 15 and a loxP site was inserted downstream of exon 15 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 15 floxed. (J:264667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcr Mutation: 62 strains or lines available

References

• Original: J:264667 Lacher SM, et al., HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis. 2017 May 25;8(5):e2824
• All: 3 reference(s)