Gt(ROSA)26Sor^{tm1(Nup214/Abl1)Cool}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Nup214/Abl1)Cool}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Cools
• MGI ID: MGI:6197969
• Synonyms: Tg(NUP214-ABL1)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Nup214/Abl1)Cool} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Nup214/Abl1)Cool} expresses 2 genes
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Abl1	expresses a Nup214/Abl1 fusion after cre mediated recombination
  Not Specified	Nup214

• Mutation details: A floxed stop-neo cassette followed by a Nup214 and Abl1 fusion gene, an IRES, and a GFP reporter were inserted via homologous recombination. (J:264234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1098 strains or lines available

References

• Original: J:264234 Vanden Bempt M, et al., Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2018 Aug 13;34(2):271-285.e7
• All: 1 reference(s)