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Rr63em1Lap
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr63em1Lap
Name: regulatory region 63; endonuclease-mediated mutation 1, Len A Pennacchio
MGI ID: MGI:6197960
Synonyms: mm636 -
Gene: Rr63  Location: Chr11:112904459-112905787 bp, + strand  Genetic Position: Chr11, Syntenic
Alliance: Rr63em1Lap page
Mutation
origin
Strain of Origin:  FVB
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-targeting using two sgRNAs (targeting TGCGTCGGTGACTGAAAAGGGGG and AGGGGAGATAGCTTCATCAGAGG) removed enhancer mm636 located 232 kb downstream of Sox9. (J:261810)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr63 Mutation:  0 strains or lines available
References
Original:  J:261810 Osterwalder M, et al., Enhancer redundancy provides phenotypic robustness in mammalian development. Nature. 2018 Feb 8;554(7691):239-243
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory