Rack1^tm1.1Cart
Targeted Allele Detail

Summary

• Symbol: Rack1^tm1.1Cart
• Name: receptor for activated C kinase 1; targeted mutation 1.1, Christine A Cartwright
• MGI ID: MGI:6197920
• Synonyms: Rack1^fl
• Gene: Rack1 Location: Chr11:48691187-48697068 bp, + strand Genetic Position: Chr11, 28.77 cM
• Alliance: Rack1^tm1.1Cart page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264359
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon2 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:264359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rack1 Mutation: 56 strains or lines available

References

• Original: J:264359 Cheng ZF, et al., Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G1-G13
• All: 3 reference(s)