Pin1^tm1.1Asano
Targeted Allele Detail

Summary

• Symbol: Pin1^tm1.1Asano
• Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1; targeted mutation 1.1, Tomoichiro Asano
• MGI ID: MGI:6197864
• Gene: Pin1 Location: Chr9:20563335-20575008 bp, + strand Genetic Position: Chr9, 7.6 cM
• Alliance: Pin1^tm1.1Asano page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264470
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2. (J:264470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pin1 Mutation: 20 strains or lines available

References

• Original: J:264470 Nakatsu Y, et al., Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the gamma subunit. J Biol Chem. 2015 Oct 2;290(40):24255-66
• All: 1 reference(s)