Wnt4^em1Amc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wnt4^em1Amc
• Name: wingless-type MMTV integration site family, member 4; endonuclease-mediated mutation 1, Andrew P McMahon
• MGI ID: MGI:6197855
• Synonyms: Wnt4-DE, Wnt4-deltaDE
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^em1Amc page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to delete the distal enhancer element (Chr4:137216986-137217756). Expression of Wnt4 is reduced in the renal vesicles of the kidneys, but not in the renal medulla as determined by in situ hybridization. (J:264647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:264647 O'Brien LL, et al., Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 Jan;14(1):e1007181
• All: 1 reference(s)