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Pomt1tm1c(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Pomt1tm1c(EUCOMM)Hmgu
Name: protein-O-mannosyltransferase 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:6197751
Synonyms: Pomt1lox
Gene: Pomt1  Location: Chr2:32236590-32255005 bp, + strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Mutant Cell Lines:  HEPD0522_6_C03, HEPD0522_6_F02
Germline Transmission:  Earliest citation of germline transmission: J:263043
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsFlp-mediated excision of the parental Pomt1tm1a(EUCOMM)Hmgu allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exons 3 and 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:263043)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pomt1 Mutation:  39 strains or lines available
References
Original:  J:263043 Rubio-Fernandez M, et al., Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy. Sci Rep. 2018 Jun 4;8(1):8543
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory