Tg(CMV-IL4)17Yoska
Transgene Detail

Summary

• Symbol: Tg(CMV-IL4)17Yoska
• Name: transgene insertion 17, Yoshie Kametani
• MGI ID: MGI:6197565
• Synonyms: NOG-hIL-4-Tg
• Transgene: Tg(CMV-IL4)17Yoska Location: unknown
• Alliance: Tg(CMV-IL4)17Yoska page

Transgene origin

• Strain of Origin: NOD.Cg-Prkdc^scid Il2rg^tm1Sug/ShiJic

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-IL4)17Yoska expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL4 (3565)

  Il4	(MGI:96556)

  human gene

• Tg(CMV-IL4)17Yoska expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cytomegalovirus	CMV

• Mutation details: The construct comprises the human cytomegalovirus immediate early (CMV IE) promoter, an SV40 intron, the human interleukin 4 cDNA, and the SV40 poly(A) signal. The construct was microinjected into NOG (NOD.Cg-Prkdc^scid Il2rg^tm1Sug/ShiJic) fertilized eggs at the pronuclear stage. Line 17 showed intermediate expression of the exogenous gene and stable germline transmission. (J:248533)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:248533 Kametani Y, et al., NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination. PLoS One. 2017;12(6):e0179239
• All: 1 reference(s)