Nckap1l^tm1.2Sixt
Targeted Allele Detail

Summary

• Symbol: Nckap1l^tm1.2Sixt
• Name: NCK associated protein 1 like; targeted mutation 1.2, Michael Sixt
• MGI ID: MGI:6197558
• Synonyms: Hem1^-
• Gene: Nckap1l Location: Chr15:103362221-103407237 bp, + strand Genetic Position: Chr15, 58.96 cM
• Alliance: Nckap1l^tm1.2Sixt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264514
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 4 and 5. (J:264514)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nckap1l Mutation: 52 strains or lines available

References

• Original: J:264514 Leithner A, et al., Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nat Cell Biol. 2016 Nov;18(11):1253-1259
• All: 3 reference(s)