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Allele Detail
Symbol: Il4i1H46-b
Name: interleukin 4 induced 1; histocompatibility 46, b variant
MGI ID: MGI:6197069
Synonyms: H46b
Gene: Il4i1  Location: Chr7:44485712-44490233 bp, + strand  Genetic Position: Chr7, 28.93 cM
Strain of Origin:  129/Sv
Allele Type:    Not Applicable (Not Applicable)
Mutation:    Nucleotide substitutions
Mutation detailsThis minor histocompatibility antigen, initially identified as being between C57BL/10ScSn and 129/Rr but also found to be between C57BL/6J and 129P3/J, is caused by a single amino acid change at residue 25, which is alanine in C57BL/6J-derived H46-a and methionine for 129-derived H46-b. The 2 nucleotide sequence variations underlying this are G73A and C74T and the core antigenic peptide from each compete similarly for binding Ab. The core antigenic peptide in H46-b is HMFVEAIPELQ. (J:264442)
Inheritance:    Semidominant
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4i1 Mutation:  90 strains or lines available
Original:  J:10078 Roopenian DC, et al., Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics. 1989;30(5):335-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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