Rr57^em1Ddu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr57^em1Ddu
• Name: regulatory region 57; endonuclease-mediated mutation 1, Denis Duboule
• MGI ID: MGI:6195729
• Synonyms: HoxD^CpG114
• Gene: Rr57 Location: Chr2:74593034-74594216 bp Genetic Position: Chr2, Syntenic
• Alliance: Rr57^em1Ddu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region, Not Applicable)
• Mutation: Intragenic deletion
• Rr57^em1Ddu involves 2 genes/genome features (Haglr, Hoxd1) View all
• Mutation details: An 1,163 bp deletion was generated with sgRNAs 5'-GAGATTCTACTCCTAAGCCC-3' and 5'-ATTCCCCGGGAAATAGCCCA-3' using CRISPR/Cas9 technology. This CpG island contains a bidirectional promoter for Hoxd1 and Haglr and also encompasses the first exons of both genes. (J:252916)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr57 Mutation: 0 strains or lines available

References

• Original: J:252916 Zakany J, et al., Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9290-E9299
• All: 1 reference(s)