Ptk2b^em1Wu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptk2b^em1Wu
• Name: PTK2 protein tyrosine kinase 2 beta; endonuclease-mediated mutation 1, Qiang Wu
• MGI ID: MGI:6195670
• Synonyms: Pyk2KO^-8bp
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^em1Wu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated recombination created an 8 bp deletion (GGCCTGAG) in exon 1. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:265543, J:326577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 55 strains or lines available

References

• Original: J:264145 Fan L, et al., Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. Elife. 2018 Jun 18;7:e35242
• All: 3 reference(s)