Rapgef4^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Rapgef4^tm1.2Ics
• Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6195642
• Gene: Rapgef4 Location: Chr2:71811584-72087818 bp, + strand Genetic Position: Chr2, 42.9 cM, cytoband C3
• Alliance: Rapgef4^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264168
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 12 and a loxP and FRT flanked neo cassette was inserted downstream of exon 13 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 12 and 13 (1.3 kb). (J:264168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef4 Mutation: 66 strains or lines available

References

• Original: J:264168 Kopperud RK, et al., Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf). 2017 Feb;219(2):441-452
• All: 5 reference(s)