Rapgef3^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1.1Ics
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6195641
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264168
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP and FRT flanked neo cassette was inserted in intron 6 and a loxP site was inserted in intron 10 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 7 - 10 (1.7 kb) floxed and a single FRT site upstream of the loxP site in intron 6. (J:264168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 49 strains or lines available

References

• Original: J:264168 Kopperud RK, et al., Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf). 2017 Feb;219(2):441-452
• All: 1 reference(s)