Rapgef4^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Rapgef4^tm1.1Ics
• Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6195636
• Gene: Rapgef4 Location: Chr2:71811584-72087818 bp, + strand Genetic Position: Chr2, 42.9 cM, cytoband C3
• Alliance: Rapgef4^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264168
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 12 and a loxP and FRT flanked neo cassette was inserted downstream of exon 13 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 12 and 13 (1.3 kb) floxed and a single FRT site upstream of the loxP site in intron 11. (J:264168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef4 Mutation: 66 strains or lines available

References

• Original: J:264168 Kopperud RK, et al., Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf). 2017 Feb;219(2):441-452
• All: 1 reference(s)