Ptk2^tm1.1Meve
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1.1Meve
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.1, Alexander Meves
• MGI ID: MGI:6195562
• Synonyms: FAK Y397F
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1.1Meve page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242026
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A tyrosine (TAT) to phenylalanine (TTT) mutation was inserted in exon 15 at codon 397 and an FRT flanked neo cassette was inserted downstream of exon 15 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:242026)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:242026 Heim JB, et al., Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3933-3938
• All: 2 reference(s)