Del(10Prtn3-Elane)1Ctnp
Targeted Allele Detail

Summary

• Symbol: Del(10Prtn3-Elane)1Ctnp
• Name: Deletion, Chr 10, Christine T N Pham 1
• MGI ID: MGI:6195558
• Synonyms: NE^-/PR3^-
• Gene: Del(10Prtn3-Elane)1Ctnp Location: Chr10:79715501-79724050 bp Genetic Position: Chr10, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264172
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(10Prtn3-Elane)1Ctnp involves 2 genes/genome features (Prtn3, Elane) View all
• Mutation details: Exon 5 of Prtn3, exon 1 of Elane and all of the intervening sequence were replaced with a floxed pgk-neo cassette via homologous recombination. (J:264172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(10Prtn3-Elane)1Ctnp Mutation: 0 strains or lines available

References

• Original: J:264172 Schreiber A, et al., Neutrophil serine proteases promote IL-1beta generation and injury in necrotizing crescentic glomerulonephritis. J Am Soc Nephrol. 2012 Mar;23(3):470-82
• All: 2 reference(s)