Clock^em1Wcsa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clock^em1Wcsa
• Name: clock circadian regulator; endonuclease-mediated mutation 1, William C Sessa
• MGI ID: MGI:6195543
• Synonyms: Clock^S845A
• Gene: Clock Location: Chr5:76357715-76452639 bp, - strand Genetic Position: Chr5, 40.63 cM
• Alliance: Clock^em1Wcsa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 mediated recombination introduced a serine (AGC) to alanine (GCC) mutation at codon 845. This mutation eliminates a phosphorylation site in this location. (J:263802)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clock Mutation: 101 strains or lines available

References

• Original: J:263802 Luciano AK, et al., CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. J Biol Chem. 2018 Jun 8;293(23):9126-9136
• All: 1 reference(s)