Gt(ROSA)26Sor^{tm1(CAG-Rspo1)Asc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Rspo1)Asc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andreas Schedl
• MGI ID: MGI:6195294
• Synonyms: R26^Rspo1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Rspo1)Asc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259735
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The following elements were inserted into intron 1: a splice acceptor, the CAG promoter, a loxP site, a neomycin resistance gene cassette, a second loxP site, an ATTB1 site, cDNA sequence for exons 2-5 of the Rspo1 gene, intronic sequence, cDNA sequence for exon 6 (including 3' UTR) a second ATTB1 site, and a poly(A) signal. This creates a conditional-ready allele that will only express the inserted gene after cre-mediated removal of the neo cassette. (J:259735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1098 strains or lines available

References

• Original: J:259735 Rocha AS, et al., The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. Cell Rep. 2015 Dec 1;13(9):1757-64
• All: 1 reference(s)