Arctm1.1Grnt
Targeted Allele Detail
|
Symbol: |
Arctm1.1Grnt |
Name: |
activity regulated cytoskeletal-associated protein; targeted mutation 1.1, Seth G N Grant |
MGI ID: |
MGI:6195285 |
Synonyms: |
ArcTAP |
Gene: |
Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
|
Alliance: |
Arctm1.1Grnt page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:254217
|
Parent Cell Line: |
E14 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted (Epitope tag) |
Mutation: |
|
Insertion
|
|
|
Mutation details: Sequence coding for a TAP (Tandem Affinity Purification) tag (containing Histidine Affinity Tag (HAT), TEV protease and 3x Flag sequences), followed by a loxP site flanked neomycin resistance gene cassette, was inserted before the translation stop codon in exon 1. The neo cassette was removed through subsequent cre-mediated recombination. This leaves an allele coding for the endogenous protein with a C-terminal TAP tag. No change in expression of the targeted gene was observed.
(J:254217)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Arc Mutation: |
26 strains or lines available
|
|
Original: |
J:254217 Fernandez E, et al., Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. Cell Rep. 2017 Oct 17;21(3):679-691 |
All: |
1 reference(s) |
|