Adamts7tm1b(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Adamts7tm1b(KOMP)Wtsi |
Name: |
ADAM metallopeptidase with thrombospondin type 1 motif 7; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6195188 |
Gene: |
Adamts7 Location: Chr9:90041420-90082155 bp, + strand Genetic Position: Chr9, 47.46 cM
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Alliance: |
Adamts7tm1b(KOMP)Wtsi page
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IMPC: |
Adamts7 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:264139
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 90059402 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 90060673. The critical exon(s) is/are thus flanked by loxP sites.A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:264139)
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Original: |
J:264139 Mead TJ, et al., The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification. JCI Insight. 2018 Apr 5;3(7) |
All: |
2 reference(s) |
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