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Pmltm1.1Ews
Targeted Allele Detail
Nomenclature
Symbol: Pmltm1.1Ews
Name: promyelocytic leukemia; targeted mutation 1.1, Eva W Stratford
MGI ID: MGI:6195046
Synonyms: PmlC62A/C65A
Gene: Pml  Location: Chr9:58218076-58249786 bp, - strand  Genetic Position: Chr9, 31.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262172
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
 
Mutation detailsTwo zinc-binding cysteine residues were substituted for two alanine residues located in the RING domain at positions 62 and 65 (C62A and C65A). A floxed neomycin resistance cassette was removed via cre-mediated recombination. (J:262172)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pml Mutation:  60 strains or lines available
References
Original:  J:262172 Voisset E, et al., Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. Blood. 2018 Feb 8;131(6):636-648
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory