Rr127^tm3.1Ebres
Targeted Allele Detail

Summary

• Symbol: Rr127^tm3.1Ebres
• Name: regulatory region 127; targeted mutation 3.1, Emery H Bresnick
• MGI ID: MGI:6194744
• Synonyms: -77^-, Gata2^tm3.1Ebres
• Gene: Rr127 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr127^tm3.1Ebres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259078
• Parent Cell Line: CJ9 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 257 bp region (chr6:8811695488117210 on build GRCm38/mm10) upstream of the Gata2 gene was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was subsequently removed through cre-mediated recombination. This region, located approximately 77 kb upstream of the ATG translation start site, is an enhancer containing two GATA motifs (WGATAR) and one E-box (CANNTG). (J:259078)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr127 Mutation: 0 strains or lines available

References

• Original: J:259078 Johnson KD, et al., Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015 Sep;1(8):e1500503
• All: 3 reference(s)