Ttrtm1.1Smoc
Targeted Allele Detail
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Symbol: |
Ttrtm1.1Smoc |
Name: |
transthyretin; targeted mutation 1.1, Shanghai Model Organisms Center |
MGI ID: |
MGI:6194707 |
Synonyms: |
TTR- |
Gene: |
Ttr Location: Chr18:20798337-20807378 bp, + strand Genetic Position: Chr18, 11.47 cM
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Alliance: |
Ttrtm1.1Smoc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:257096
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Hypomorph) |
Mutation: |
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Single point mutation
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Mutation details: Exon 3 containing a G to C point mutation at the 107th base resulting in a glycine to arginine change at amino acid 83 (Gly83Arg) was introduced into the gene via homologous recombination. A FRT-flanked PGK-neo cassette and a loxP site were inserted upstream of exon 3. Flp-mediated recombination removed the selection cassette. Western blot analysis indicates lower protein expression than in wild-type mice.
(J:257096)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ttr Mutation: |
44 strains or lines available
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Original: |
J:257096 Ran LX, et al., A mouse model of a novel missense mutation (Gly83Arg) in a Chinese kindred manifesting vitreous amyloidosis only. Exp Eye Res. 2018 Feb 1;169:13-19 |
All: |
1 reference(s) |
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