Nr1h3^tm1.1Ipta
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1.1Ipta
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, Ines Pineda-Torra
• MGI ID: MGI:6194379
• Synonyms: S196A^fl
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1.1Ipta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263851
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Single point mutation
• Mutation details: The targeting construct inserted into intron 4 a loxP site, alox2272 site, a reverse orientation modified exon 5 in which a nucleotide substitution (T to G) results in the amino acid substitution of alanine for serine at position 196 (S196A; ENSMUSG00000002108), and a loxP site. An additional lox2272 site was inserted downstream of the endogenous exon 5. Flp-mediated recombination removed the selection cassette inserted downstream of the modified exon 5. (J:263851)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 36 strains or lines available

References

• Original: J:263851 Gage MC, et al., Disrupting LXRalpha phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6556-E6565
• All: 4 reference(s)